Facial hyperpigmentation is common, and can cause significant cosmetic disfigurement with subsequent emotional impact. It is important to approach facial hyperpigmentation, which is much more common in patients of brown or black skin colour , in a logical way. As such the conditions have been grouped in this chapter as follows:. Please click on images to enlarge or download. All named individuals and organisations maintain copyright for the relevant images.
We hope you like our faster and more stable platform. Please tell us if you experience any problems. DermNet provides Google Translate, a free machine translation service. Note that this may not provide an exact translation in all languages. Pigmentation may be induced by a wide variety of drugs; the main ones implicated include non-steroidal anti- inflammatory drugs NSAIDs , phenytoin, antimalarials , amiodarone, antipsychotic drugs, cytotoxic drugs , tetracyclines , and heavy metals. Some drugs may cause fixed drug eruption , which is followed by localised hyperpigmentation and gradually fades.
Hyperpigmentation is the darkening of an area of skin or nails caused by increased melanin. Hyperpigmentation can be caused by sun damage, inflammation , or other skin injuries, including those related to acne vulgaris. Many forms of hyperpigmentation are caused by an excess production of melanin. Melanin is produced by melanocytes at the lower layer of the epidermis.
Skin color is determined by melanin and other chromophores and is influenced by physical factors ultraviolet radiation and other endocrine, autocrine, and paracrine factors. Hyperpigmentation may be circumscribed or diffuse. Diffuse hyperpigmentation can be multifactorial in origin; hence, a multipronged approach is needed in such cases.